Diabetic Model
STZ-induced Diabetic Model for General Diabetic Studies
Diabetes in humans induces chronic complications such as cardiovascular damage, cataracts and retinopathy, nephropathy and polyneuropathy. The most common animal model of human diabetes is streptozotocin (STZ)-induced diabetes in the rat.
Objective:
Assesses the anti-diabetic efficacy of Test Product over a period of 4 weeks post STZ administration in rats by terminal blood glucose measurement and oral glucose tolerance test.
Literature Review
This section highlights references for:
STZ-induced diabetic model development using SD rat
Testing anti-diabetic efficacy of Test Product through oral intervention
Blood glucose measurement and oral glucose tolerance test (OGTT)
Siti Balkis Budin.pdfProject Workflow
project workflow.pptxThis section highlights brief 28-days methodology of:
Duration of study
Animal model development
Oral treatment using Test Product and positive control drug
Evaluation of Test Product efficacy
Items Required
Animal source
Non-SPF SD rats, 6 weeks old
Diet
High quality autoclaved rodent maintenance diet
Bedding
High absorbability Corn cob bedding
Housing
Standard polycarbonate cages with solid bottoms and sides with stainless steel lids as recommended in Animal Husbandry Guideline
Consumables
Needles, anaesthesia reagents, streptozotocin, etc
Sample Report
Resources
Estimated Budget
Experiment Design
Sample Ethnic Form
Sample Report